DR Farms 2016 Litter
DR Farms litter delivery day was April 17, 2016. This is Prince & Pepper's first litter. Stay tuned for updated information. The genetics of this litter is described below. Follow the puppies on Facebook. 3 Healthy puppies are born 1 male and 2 female. Sable & White Collies
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What you need to know about MDR1, PRA and CEA when it comes to your Collie from DR Farms
DR Farms makes every effort to improve the collie breed in our breeding program. We particularly want to improve the listed genetic characteristics with each successive pair of dogs that we breed. As with every program you have to weigh the importance of, the impact on future breeding and the health of the offspring. Since our goal is to breed for family pets with show and entertainment potential we have a little more flexibility in the genetic characteristics of our dogs. We do plan on improving to the point that we can confidently recommend future breeding of the offspring that will improve the breed by eliminating health issues for future generations. Until we can get the right genetics along with temperament and coat colors we will continue to breed for family pets, farm dogs, show and entertainment potential. This was a mouth full and for most of us we want to know what does this all mean to me and the puppy I choose? So let me break it down for you:
MDR1 is the most important long term issue when it comes to the health of your collie. It is the one that will impact medication and the quantity of the medication you want your collie to be exposed to. Our current dogs Pebbles and Rocky are Normal/Normal and Mutant/Mutant which means that each of the offsprings will be:
- Mutant/Normal - These dogs carry the mutation and may pass on the mutant gene to their offspring. These dogs may experience toxicity after normal doses of loperamide (Imodium), and some anticancer drugs, and high doses of ivermectin (greater than 50 micrograms per kilogram)
What heartworm prevention products can I use if my dog has the MDR1 mutation?
- Fortunately, the dose of ivermectin, selamectin, milbemycin and moxidectin in the commercial heartworm preparations are low enough to be used safely even in dogs with the MDR1 mutation. It is only when the drugs are used at high doses, such as those used to treat mange (50 times higher dose than the heartworm prevention dose), that dogs with the mutation will develop neurological toxicity. Attempting to use large animal formulations of these drugs is likely to cause neurological toxicity because it is difficult to accurately measure.
Collie Eye Anomaly - CEA
CEA is an eye condition that depending on the genetics of the dog can manafest itself from no vision issues to blindness. It is our commitment to the collie breed that we will not mate two dogs that do not have certainty of being less than Normal/Recessive and our ultimate goal is to breed pairs that will be exclusively Normal/Normal for all offspring. One step at a time however.
CEA is a severe eye issue but only when the puppy is Recessive/Recessive and whatever the puppy is identified as at 9 weeks is what the puppy will have for their entire life. Most breeders understand there are far worse things to be concerned about than CEA but also most breeders want to minimize CEA by ensuring that one of the dogs is Dominate/Dominate for CEA and then none of the puppies will display any eye issues. If the breeder wants to offer the dog for breeding purposes then you want to have a Dominate/Dominate male and female otherwise they should be presented as puppies for family or show potential. With all that said DR Farms currently has a Dominate/Dominate female and a Dominate/Recessive Male which provides for a 50% chance for Dominate/Recessive and 50% Dominate/Dominate CEA clasification by genetics. Meaning none of the puppies we have for sale will ever demonstrate any CEA characteristics. :)
Progressive Retinal Atrophy (PRA)
This is probably the most severe of the three conditions that we screen for in our breeding program. The dog will become increasingly blind. Since MDR1 and CEA are manageble and are known upfront. PRA on the other hand is a progressive desease and we strive to eliminate this from our breeding so that we don't have PRA characteristics at all.
- PRA is an inherited disease of the retina (the "film in the camera") in dogs, in which the eyes are genetically programmed to go blind. PRA occurs in both eyes simultaneously and is nonpainful. There are many different types of inherited retinal degenerative diseases in purebred dogs, and discussing these are beyond the scope of this article. PRA occurs in most breeds of dogs and can occur in mixed breeds also. It is recessively inherited in all breeds studied, with the following exceptions: PRA is dominantly inherited in Old English Mastiffs and Bullmastiffs, and PRA is sex-linked and found primarily in male dogs in the Siberian Husky and Samoyed breeds.
- DR Farms have no dogs that have PRA. The genotype for them are Normal. Bottom line is that none of the prodogy will develop rcd2 form of PRA
Beginning with our 2015 litter each of the dogs will have documentation on their page regarding each of these issues.